To understand calf performance, study bees!

Lifestart themes
Metabolic programming

Key takeaways from the article:

  • Epigenetics describes the mechanisms by which genes are expressed or inhibited
  • These mechanisms are similar between bees and calves
  • Queen bees and worker bees are genetically identical
  • Due to differences in early life nutrition, they develop into completely different phenotypes

The mechanisms behind metabolic programming in calves are the same as in bees

What's the link between enhanced calf nutrition, higher milk output and honeybees? If you said DNA methylation then you are no doubt a confirmed epigeneticist! As for the rest of us, to better understand the relationship let's start with a look at bee differentiation within the hive. All-female bee larvae contain the same DNA—in fact, they are genetic clones—and yet there is significant differentiation between the queen and worker bees. Because both castes are exclusively female, (the reproducing males are called drones), this difference is not accounted for by sex. So, how can two clones become different? The answer is found in epigenetics.

Impact of early life nutrition in honey bees

While two organisms may be genetically identical, the way the genes are expressed allows for very large differences. Epigenetics describes the mechanisms by which individual genes are either expressed or inhibited. It is as though each gene is associated with a dimmer switch that can either attenuate or amplify its importance, (i.e. its impact on the phenotype), according to changes in the organism's external and internal environment. For queen bees, the transformational environmental changes are linked to the ingestion of royal jelly.

Royal jelly is composed of 67% water, 12.5% crude protein including a variety of amino acids, 11% simple sugars and 5% fatty acids. It also contains multiple trace minerals, enzymes and vitamins. All larvae are fed royal jelly for the first three days, however the queen feasts on it for a lifetime – and in great quantities. But the catalyst behind queen differentiation is a specific component of the protein called 57-kDa, better known as Royalactin. Royalactin increases body size and ovary development and shortens the developmental time in honeybees. The difference between queen and worker castes is one of the most striking examples found in the nature of phenotypic polymorphism due to epigenetic factors.


Epigenetic phenotypic polymorphism in honey bees at the cellular level

Fed royal jelly during lifetime (food quantities = 10x more than workers) Fed royal jelly for 3 days, then downgraded mixture of pollen and honey
Rapid growth: 200mg final weight 100 mg final weight
Lifetime = 3 years Lifetime = 1 month
Maturation of reproductive organs (up to 2000 eggs per day) Rudimentary, inactive ovaries
At the cellular level, the phenotypic polymorphism of honeybees is mediated by a process called CpG methylation. CpG methylation is able to establish and maintain diverse patterns of gene expression from the same genome under specific temporal, spatial and environmental conditions—the internal and external environment pressures mentioned above. This non-reproductive modification of genomic DNA provides a link between genomes and the environment and may result in a phenotypic change that is heritable, independently of DNA mutation. Paradoxically, it was only relatively recently that the process of genomic methylation was established in invertebrates. This was because the technology was not yet available to detect modifications (methylomes) with very low methylation levels.


What about other species?

More about Metabolic programming

A LifeStart feeding schedule alters serum metabolomic profiles and hepatic function in calves

Elevated levels of pre-weaning nutrition increase growth and change protein and energy metabolism and hepatic function of calves.
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From genetics to epigenetics

Environmental factors such as early life nutrition can influence the genome and future productivity of animals, a phenomenon known as "metabolic programming".
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Pre-weaning nutrition has a big impact on metabolism later in life

In the Kempenshof trial, effects of metabolic programming on life-time performance of dairy calves will be studied for the entire life of the animals.
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LifeStart Pillars

Colostrum Management
Weaning Strategies
Calf to heifer

LifeStart Themes

Metabolic Programming
Glucose metabolism
Role of fat in calf nutrition
Lactobalance, hydration, and osmoregulation
Most LifeStart science articles on this site relate to a particular stage of the life of a calf or dairy cow. However, some general themes are not related to a particular stage of life. For a full understanding of LifeStart science, please review the information related to the 4 themes above: