“The first three days are critical”: Danish research aims to improve survival of low birth weight piglets

  • 2026
  • LACTATION

Sarah Mikesell, editor of The Pig Site working in collaboration with LifeStart Swine, recently spoke to Dr. Johannes Gulmann Madsen, an associate professor in Monogastric Animal Nutrition at the University of Copenhagen in Denmark. Dr. Madsen’s research has focused on intrauterine growth restriction, low birth weight piglets, gut health, optimizing and developing milk replacer and infant formula, and using a pig as a model for human nutrition and physiology.

The increasing size of litters has brought with it a mounting industry challenge: low birth weight piglets. While genetic advancements have boosted productivity, they have also resulted in more small, vulnerable piglets at birth. These piglets often struggle to compete for colostrum, are more prone to hypothermia and face a significantly higher risk of death.  

Dr. Madsen is working to understand why these piglets fail to thrive, or even catch up with their pen mates, and how to change that trajectory. 

“From my point of view, the biggest challenge low birth weight pigs pose is that they increase the mortality rate in the litter,” said Dr. Madsen. “They simply die because they have low energy reserves, hypothermia and/or undernutrition.” 

The long-term effects are just as concerning. According to Madsen, low birth weight piglets that survive often lag behind their litter mates throughout their lifespan. They grow more slowly, have poorer feed efficiency and typically reach market weight later. Even at slaughter, their carcasses may yield less desirable traits, ultimately diminishing economic returns. 

“They probably have lower quality carcass traits,” Madsen explained. “So overall, they are impairing the economy and the sustainability of the pig production.” 

How low is “low”? 

There’s no universal definition of a low birth weight piglet. In Denmark, where larger litters are the norm, Dr. Madsen tends to view piglets under 800 grams as particularly at risk. However, he noted that some industry professionals set the cut-off as high as 1.2 kilograms. 

“It really depends on the genetics that you use and the litter size,” he said. “But I would say below 800 grams, they start to get complicated. They are tough.” 

The lasting impact of IUGR 

A major contributing factor to low birth weight is intrauterine growth restriction (IUGR), a condition in which the fetus fails to develop properly during gestation. Not all low birth weight piglets suffer from IUGR – some may simply be small but otherwise healthy. However, identifying the difference is not easy. 

“There is a fairly great proportion that have been exposed to IUGR, and they will be negatively impacted the rest of their life,” said Madsen. “It’s very difficult to reverse the negative impact.” 

The implications for producers are serious: many of these piglets consume resources while delivering reduced performance throughout their lifespan. Finding effective interventions is important not just for animal welfare but for the economic sustainability of the industry.

Piglets drinking from a feeder

Exploring artificial rearing solutions 

In his pursuit of better outcomes, Madsen has co-led several research trials exploring artificial rearing strategies for vulnerable piglets. The trials are conducted under controlled conditions for research purposes and tested whether early, targeted interventions could improve survival and growth. 

One approach involved placing piglets in “rescue decks” immediately after birth and feeding them a high-fat, high-protein milk replacer designed to mimic sow’s milk. The goal was to provide extra nutrition and warmth without competition from larger litter mates. However, the results were mixed. 

“We might have a simple theory that if we just supply sufficient amounts of optimized milk replacer, they will just eat it because they are hungry,” said Madsen. “But that just didn’t happen.” 

In another trial, Madsen and his colleagues and collaborators introduced temporary artificial rearing within the farrowing pen. Small piglets were isolated for six-hour windows over three days, given milk replacer, and then rotated back out. This approach showed some promise in improving early intake and survival during the most critical period of life, but gains were limited. 

“They survived and were growing slowly and they did eat the milk replacer,” said Madsen. “But after the three days where we had the confinement, it was tough again.” 

These outcomes led to one of the central conclusions of Madsen’s work: early intervention is essential, but the window of opportunity is narrow. 

“We know we need to do something during the first three days of life, which is when the mortality rate is the greatest,” he said.

An artificial sow udder mimics nursing 

To help piglets better engage with artificial nutrition, Madsen’s collaborators developed an innovative tool: a simulated sow udder. Created by Danish agricultural research group SEGES, this “artificial udder” included soft teats to mimic the natural nursing experience. 

“There have been some older studies that suggested that piglets are more likely to drink if it’s an artificial udder rather than a cup,” Madsen noted. “But they can learn to drink from the cup very early, that’s for sure.” 

More research is needed to determine which feeding methods are most effective, and how to encourage consumption among the smallest and weakest animals. Madsen pointed out that behavioral stress, environmental conditions, and even social cues from litter mates may play a role. 

“We don’t know enough about how we can get them to eat,” he admitted. “And we don’t know enough about how they respond to the artificial rearing?” 

Practical on-farm strategies 

Many farms in Denmark already use nurse sows to support the care of low birth weight piglets. While effective in redistributing feeding pressure, nurse sow systems require careful management and come with trade-offs. 

“If you use the nurse sows, you have to move the piglets around a lot and you don’t know the age of the piglets,” Madsen said. “And that may cause a problem when you wean the piglets, because the development of the digestive system depends on age and not size.” 

Moreover, high piglet movement can increase the risk of disease transmission and labor costs. As a result, some researchers advocate combining nurse sow use with other strategies like temporary artificial rearing or supplemental nutrition. 

“You could maybe combine different strategies – maybe use nurse sows only for the small piglets, for example, for the IUGR, in combination with some temporary artificial rearing and some optimized milk replacer,” he suggested. 

However, the economics of such systems remain a concern for producers.  

“They will not buy a very expensive milk replacer if they don’t get anything out of it,” Madsen noted. 

Can sow nutrition help? 

Madsen has explored how sow nutrition during gestation can influence piglet birth weight and survivability. His work includes studying the effects of l-arginine supplementation. 

“It has some effect enlarging the myofibers or the muscle cells, which offers the potential for better muscle development in utero that could enhance postnatal growth performance,” he said.  

There is also growing interest in strategies to reduce the duration of farrowing. If piglets are born faster and more efficiently, they may have a better shot at getting colostrum before becoming hypothermic or energy deficient. 

“If you get piglets out faster, there is a longer time for all the pigs to get sufficient amounts of colostrum,” Madsen noted. 

Researchers have also considered glucose supplementation for sows before farrowing and the use of colostrum alternatives.

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